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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/52923

Title: Effect of Chitosan on Hepatic Drug-metabolizing Enzymes and Oxidative Stress in Rats Fed on a Low- and High-fat Diet.
Authors: Hsien-Tsung Yao
Chong-Kuei Lii
Ruey-Hwang Chou
Jia-Hsuan Lin
Hui-Ting Yang
Meng-Tsan Chiang
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: Chitosan
drug-metabolizing enzymes
oxidative stress
Date: 2010-03
Issue Date: 2020-02-10T06:30:15Z
Publisher: Journal of Agricultural and Food Chemistry
Abstract: Abstract: Chitosan is sold worldwide as a lipid-lowering functional food and may be taken with certain medications. To investigate the effect of chitosan on drug-metabolizing enzymes and oxidative stress in the liver, male Wistar rats were fed a low- or high-fat diet with cellulose or chitosan for 4 weeks. A significant decrease in cytochrome P450 (CYP) 3A-catalyzed testosterone 6β-hydroxylation in liver microsomes was observed in rats fed the chitosan with low- and high-fat diets. The expression of CYP 3A1 and 3A2, however, was suppressed by chitosan in rats fed the low-fat diet only. Furthermore, rats fed the low-fat diet with chitosan had lower hepatic glutathione S-transferase (GST) activity and superoxide dismutase activity and higher total tissue and microsomal lipid hydroperoxides. Hepatic α-tocopherol was lower in rats fed the chitosan-containing diet. The results suggest that chitosan is likely to modulate CYP 3A activity and protein expression and GST activity partially in a dietary fat-dependent manner. This change may cause a decrease in the metabolism of drugs catalyzed by these enzymes in liver tissues. Moreover, decrease of α-tocopherol level and SOD activity by chitosan partly accounts for the increase of hepatic lipid peroxidation.
Relation: 58 pp 5187-5193
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/52923
Appears in Collections:[食品科學系] 期刊論文

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