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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/52917

Title: Characterization of tea catechins-loaded nanoparticles prepared from chitosan and an edible polypeptide.
Authors: Guo-Jane Tsai
Deh-Wei Tang
Shu-Huei Yu
Yi-Cheng Ho
Bing-Quan Huang
Hao-Ying Hsieh
Hsing-Wen Sung
Fwu-Long Mi
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: Chitosan
Date: 3013-01
Issue Date: 2020-02-07T08:43:28Z
Publisher: Scisence Journals
Abstract: Abstract: Tea catechins, the major polyphenolic compounds in green tea are potent antioxidant with numerous attributed health benefits. However, oral administration of the oxidation-sensitive compounds is limited by the harsh environment of the gastrointestinal tract (GIT) and become an important challenge. In this study, self-assembled nanoparticles composed of chitosan (CS) and an edible polypeptide, poly(γ-glutamic acid) (γ-PGA) were prepared for the delivery of tea catechins. The tea catechins-loaded nanoparticles were pH-responsive and demonstrated different tea catechins release profiles in simulated gastrointestinal tract (GI tract) media. Sustained free radical (DPPH and ABTS+) scavenging assays showed that the antioxidant activity of tea catechins was retained by the nanoparticles. The nanoparticles with a positive surface charge could transiently open the tight junctions between Caco-2 cells and thus increased the paracellular transport of tea catechins. These results demonstrate that CS/γ-PGA nanoparticles can be effective as a carrier for oral delivery of tea catechins with effective antioxidant activity.
Relation: 30(1) pp 33-41
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/52917
Appears in Collections:[食品科學系] 期刊論文

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