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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/52910

Title: Effect of chitosan molecular weight on anti-inflammatory activity in the RAW 264.7 macrophage model
Authors: Shun-HsienChang
Guo JaneTsai
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: Chitosan
RAW 264.7 macrophages
Mitogen-activated protein kinase
Date: 2019-06
Issue Date: 2020-02-07T07:29:16Z
Publisher: International Journal of Biological Macromolecules
Abstract: Abstract: Chitosan (300 kDa) was degraded by cellulase to chitosans with molecular weights (MWs) of 156, 72, 7.1, and 3.3 kDa and a chitooligosaccharide mixture (COS). Effects of these on NO secretion, cytokine production, and mitogen-activated protein kinase pathways in lipopolysaccharide (LPS)-induced murine RAW 264.7 macrophages were investigated. Larger chitosans (300, 156, 72 kDa) significantly inhibited NO production, whereas smaller chitosans (7.1 & 3.3 kDa, COS) increased NO production. The 156 and 72 kDa chitosans significantly inhibited TNF-α and IL-6 production, whereas the 7.1 kDa chitosan and COS significantly induced their production. The 156 and 72 kDa chitosans inhibited NF-κB activation and iNOS expression by binding to the CR3 (for 156 kDa chitosan), or CR3 and TLR4 receptor (for 72 kDa chitosan). The smaller chitosans (e.g. 7.1 kDa chitosan and COS) activated NF-κB and enhanced iNOS expression by binding to CD14, TLR4, and CR3 receptors to activate JNK signaling proteins.
Relation: 131(15) pp 167-175
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/52910
Appears in Collections:[食品科學系] 期刊論文

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