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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51795

Title: Electrotaxis of lung cancer cells in a multiple-electric-field chip
Authors: Ching-Wen Huang
Ji-Yen Cheng
Meng-Hua Yen
Tai-Horng Young
Contributors: 國立臺灣海洋大學:機械與機電工程學系
Keywords: Electrotaxis
Microfluidic
Cancer metastasis
Lung cancer cell
Metastasis–electrotaxis
Date: 2009-05
Issue Date: 2018-12-24T06:00:37Z
Publisher: Biosensors and Bioelectronics
Abstract: Abstract: We report a microfluidic cell culture chip that was used for long-term electrotaxis study on a microscope. The cellular response under three different electric field strengths was studied in a single channel microfluidic chip. Electric field (EF) inside the microchamber was numerically simulated and compared to the measured value. Lung cancer cell lines with high and weak metastasis potential, CL1–5 and CL1–0, respectively, were used to demonstrate the function of the multi-field chip (MFC). The two cell lines exhibited greatly different response under the applied EF of E = 74–375 mV/mm. CL1–5 cells migrated toward the anode while CL1–0 cells did not show obvious response. Under the applied EF, cell orientation was observed accompanying the cell migration. Judging from the different temporal responses of the orientation and the migration, it is proposed that the two EF-induced responses may involve different signaling pathways.
Relation: 24(12) pp.3510-3516
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51795
Appears in Collections:[機械與機電工程學系] 期刊論文

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