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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51787

Title: Modulating chemotaxis of lung cancer cells by using electric fields in a microfluidic device.
Authors: Yu-Chiu Kao
Meng-Hua Hsieh
Chung-Chun Liu
Huei-Jyuan Pan
Wei-Yu Liao
Ji-Yen Cheng
Po-Ling Kuo
Chau-Hwang Lee
Contributors: 國立臺灣海洋大學:機械與機電工程學系
Date: 2014-04
Issue Date: 2018-12-24T02:24:08Z
Publisher: Biomicrofluidics
Abstract: Abstract: We employed direct-current electric fields (dcEFs) to modulate the chemotaxis of lung cancer cells in a microfluidic cell culture device that incorporates both stable concentration gradients and dcEFs. We found that the chemotaxis induced by a 0.5 μM/mm concentration gradient of epidermal growth factor can be nearly compensated by a 360 mV/mm dcEF. When the effect of chemical stimulation was balanced by the electrical drive, the cells migrated randomly, and the path lengths were largely reduced. We also demonstrated electrically modulated chemotaxis of two types of lung cancer cells with opposite directions of electrotaxis in this device.
Relation: 8(2)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51787
Appears in Collections:[機械與機電工程學系] 期刊論文

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