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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51783

Title: A compact 3D-printed interface for coupling open digital microchips with Venturi easy ambient sonic-spray ionization mass spectrometry.
Authors: Jie-Bi Hu
Ting-Ru Chen
Chia-Hsien Chang
Ji-Yen Cheng
Yu-Chie Chen
Pawel L. Urban
Contributors: 國立臺灣海洋大學:機械與機電工程學系
Date: 2015-01
Issue Date: 2018-12-24T02:08:55Z
Publisher: The Analyst
Abstract: Abstract: Digital microfluidics (DMF) based on the electrowetting-on-dielectric phenomenon is a convenient way of handling microlitre-volume aliquots of solutions prior to analysis. Although it was shown to be compatible with on-line mass spectrometric detection, due to numerous technical obstacles, the implementation of DMF in conjunction with MS is still beyond the reach of many analytical laboratories. Here we present a facile method for coupling open DMF microchips to mass spectrometers using Venturi easy ambient sonic-spray ionization operated at atmospheric pressure. The proposed interface comprises a 3D-printed body that can easily be "clipped" at the inlet of a standard mass spectrometer. The accessory features all the necessary connections for an open-architecture DMF microchip with T-shaped electrode arrangement, thermostatting of the microchip, purification of air (to prevent accidental contamination of the microchip), a Venturi pump, and two microfluidic pumps to facilitate transfer of samples and reagents onto the microchip. The system also incorporates a touch-screen panel and remote control for user-friendly operation. It is based on the use of popular open-source electronic modules, and can readily be assembled at low expense
Relation: 140(5) pp.1495-1501
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51783
Appears in Collections:[機械與機電工程學系] 期刊論文

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