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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51509

Title: PBPK/PD assessment for Parkinson's disease risk posed by airborne pesticide paraquat exposure.
Authors: Cheng YH
Chou WC
Yang YF
Huang CW
How CM
Chen SC
Chen WY
Hsieh NH
Lin YJ
You SH
Liao CM
Contributors: 國立臺灣海洋大學:食品安全與風險管理研究所
Keywords: PBPK/PD
Parkinson’s disease
Population exposure-response function
Probabilistic risk assessment
Date: 2018-02
Issue Date: 2018-12-05T08:32:36Z
Publisher: Environmental Science and Pollution Research
Abstract: Abstract: Exposure to several specific pesticides has led to an increase of Parkinson's disease (PD) risk. However, it is difficult to quantify the PD population risk related to certain pesticides in regions where environmental exposure data are scarce. Furthermore, the time trend of the prevalence and incidence of PD embedded in the background relationship between PD risk and pesticide exposures has not been well characterized. It has been convincingly identified that a key pesticide associated significantly with an increased risk trend of PD is paraquat (PQ). Here, we present a novel, probabilistic population-based exposure-response approach to quantify the contribution from PQ exposure to prevalence risk of PD. We found that the largest PQ exposure contributions occurred in its positive trend during 2004-2011, with the PQ contributing nearly 21 and 24%, respectively, to the PD prevalence rates among the age groups of 70-79 and ≥ 80 years in Taiwan. We also employed the present population risk model to predict the PQ-induced PD prevalence based on the projected rates of increase in PQ exposure associated with age-specific population. The predicted outcome can be used as an early warning signal for public health authorities. We suggest that a mechanistic understanding of the contribution of a specific pesticide exposure to PD risk trends is crucial to enhance our insights into the perspective on the impacts of environmental exposure on the neurodegenerative diseases.
Relation: 25(6) pp.5359-5368
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51509
Appears in Collections:[食品科學系] 期刊論文

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