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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51268

Title: Dietary cholestin (red yeast extract) reduces toxicity of oxidized cholesterol in rats
Authors: Y.-H. Yeh
Y.-T. Lee
You-Liang Hsieh
Deng-Fwu Hwang
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: cholestin
oxidized cholesterol
toxic effect
rats
liver function
Date: 2010-06
Issue Date: 2018-11-20T07:16:16Z
Publisher: Journal of Food and Drug Analysis
Abstract: Abstract: This study focused on the effects of dietary cholestin (red yeast extract) on the toxicity of oxidized cholesterol in rats. The rats were divided into eight groups and fed with or without supplement of 1% cholestin and 3% oxidized cholesterol in their diets for 8 weeks. It was found that cholestin could improve the body weight decrease and the glutathione (GSH) level in the liver, and increase of liver and kidney weight to body weight ratio, and thiobarbituric acid-reactive substances (TBARS) level in the liver of rats caused by oxidized cholesterol (P < 0.05). It also reduced the plasma content of alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP), indicating that cholestin could prevent the hepatotoxicity induced by oxidized cholesterol (P < 0.05). In addition, cholestin possessed recovering effect and a short-term preventing effect on the toxicity of oxidized cholesterol in rats. Taking all these data together, cholestin may play an important role in diminishing the toxic effects of oxidized cholesterol in rats.
Relation: 18(3) pp.211-220
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51268
Appears in Collections:[食品科學系] 期刊論文

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