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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51197

Title: Analysis of the association between transcription factor binding site variants and distinct accompanying regulatory motifs in yeast
Authors: Chiang S
Swamy KB
Hsu TW
Tsai ZT
Wang D
Tsai HK
Contributors: 國立臺灣海洋大學:資訊工程學系
Keywords: Transcription factor binding site
Variable position
Gene expression
Date: 2012-01
Issue Date: 2018-11-15T08:27:11Z
Publisher: Gene
Abstract: Abstract: It is generally accepted that genes are regulated by the interactions between transcription factors (TFs) and their binding sites (TFBSs). Some studies have demonstrated that nucleotide variants at variable positions in TFBSs affect yeast gene regulation. Furthermore, variable positions in TFBSs in association with distinct accompanying regulatory motifs of other TFs (i.e., co-TFs) can also impact gene regulation in eukaryotes. Given that, even low-affinity TF–DNA interactions are abundant in vivo; we used both low- and high-affinity TFBSs and performed a genome-wide analysis of associations between variable positions and co-TFs. We found that, in Saccharomyces cerevisiae, approximately 14% of the variable positions in TFBSs demonstrate such associations. These associations occurred in close proximity on the same promoters (i.e., highly co-localized). Moreover, such associations were highly conserved between sensu stricto yeasts and also influenced gene expression, which were consistent with enriched functional categories.
Relation: 491(2) pp.237-245
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51197
Appears in Collections:[資訊工程學系] 期刊論文

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