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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51192

Title: Hypoxia-inducible factor 2-alpha participates in the regulation of intersegmental vessels angiogenesis and neuromast deposition
Authors: Chi-Fu Chou
Han-Jia Lin
Chih-Yu Tsai
Tzung-Yi Lin
Hsin-Yu Chung
Chia-Yin Chiang
Chung-Hao Li
Tun-Wen Pai
Chin-Hwa Hu
Wen-Shyong Tzou
Contributors: 國立臺灣海洋大學:資訊工程學系
Keywords: hypoxia-inducible factor 2-alpha
lymphoid enhancer factor 1
spleen tyrosine kinase
intersegmental vessels
lateral line primordium
Date: 2016-04
Issue Date: 2018-11-15T07:36:51Z
Publisher: Journal of Marine Science and Technology
Abstract: Abstract: Subtle morphogenesis begins during trunk development after
the segmentation period in zebrafish. Sprouting angiogenesis
forms the trunk vascular system after the extension of the dorsal
aorta and cardinal veins. The posterior lateral line primordium
migrates from head to tail, forming the sensory organs on the
skin. It is still unclear whether this morphogenesis requires
several master regulators to control the ongoing process. Hypoxia-inducible
factor 2-alpha (Hif2-alpha) plays an essential
role in the maturation of both central neural system and digestive
system during embryogenesis. We hypothesized that
Hif2-alpha also regulates trunk development. Through
loss-of-function experiments, we found that Hif2-alpha, but not
Hif1-alpha, is necessary for angiogenesis and the formation of
neuromasts in the trunk. Hif2-alpha regulates the expression of
spleen tyrosine kinase (Syk), maintaining sprouting in the trunk.
Furthermore, Hif2-alpha also regulates lymphoid enhancer
factor 1 (Lef1), moderating the deposition of neuromasts. The
regulation of syk and lef1 expression by Hif2-alpha occurs
through the direct binding of Hif2-alpha to the hypoxia-responsive
elements (HRE) of syk and lef1. This study provides
the first evidence that Hif2-alpha plays a pivotal role in the
vertebrate embryonic development of intersegmental vessels
and the mechanosensory system in the zebrafish trunk
Relation: 24(2) pp.347 - 358
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51192
Appears in Collections:[資訊工程學系] 期刊論文

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