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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51191

Title: A genome-wide association study on amyotrophic lateral sclerosis in the Taiwanese Han population
Authors: Chi-Jim Chen
Chien-Ming Chen
Tun-Wen Pai
Hao-Teng Chang
Chi-Shin Hwang
Contributors: 國立臺灣海洋大學:資訊工程學系
Keywords: Gene Ontology
amyotrophic lateral sclerosis
genetic biomarker
genome-wide association study
neurodegenerative disease
Date: 2016-06
Issue Date: 2018-11-15T07:29:43Z
Publisher: Biomarkers in Medicine
Abstract: Abstract: Identification of mutations in patients with amyotrophic lateral sclerosis (ALS) in a genome-wide association study can reveal possible biomarkers of such a rapidly progressive and fatal neurodegenerative disease. It was observed that significant single nucleotide polymorphisms vary when the tested population changes from one ethnic group to another. To identify new loci associated with ALS susceptibility in the Taiwanese Han population, we performed a genome-wide association study on 94 patients with sporadic ALS and 376 matched controls. We uncovered two new susceptibility loci at 13q14.3 (rs2785946) and 11q25 (rs11224052). In addition, we analyzed the functions of all the associated genes among 54 significant single nucleotide polymorphisms using Gene Ontology annotations, and the results showed several statistically significant neural- and muscle-related Gene Ontology terms and the associated diseases.
Relation: 10(6) pp.597-611
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51191
Appears in Collections:[資訊工程學系] 期刊論文

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