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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51183

Title: Reconstruction of rapidly acquired Germanium-68 transmission scans for cardiac PET attenuation correction
Authors: Hsu BL
Case JA
Moser KW
Bateman TM
Cullom SJ
Contributors: 國立臺灣海洋大學:資訊工程學系
Keywords: Cardiac positrom emission tomography
ordered-subsets expectation maximization with Bayesian prior
transmission reconstruction
germanium 68
rubidium 82
Date: 2007-09
Issue Date: 2018-11-15T03:27:13Z
Publisher: Journal of nuclear cardiology
Abstract: Abstract: Background
Transmission (TX) scan time by use of radionuclide sources for cardiac positron emission tomography prolong imaging and increase the likelihood of patient motion artifacts. A reconstruction algorithm combining ordered-subsets expectation maximization with a Bayesian prior was developed and applied to rapid Germanium-68 (Ge-68) TX scans.

Methods and Results
A cardiac phantom with Fluorine-18 (Fl-18) was used to determine a minimal count threshold for Ge-68 TX scanning. Images were acquired over a count range from 2.5 ×106 to 8×107 and for a high-count scan of 1.6×109 counts to study reconstruction parameters and to determine the minimum TX count threshold. The method was compared against clinical 4-minute TX scans in ten Rubidium-82 (Rb-82) rest/stress myocardial perfusion studies (body mass index, 30±4kg/m2). The minimal count threshold was 20×106, and the mean scan time for the Rb-82 studies was 70.5±3.4 seconds. More than 90% of the segmental scores computed from images acquired via rapid TX scans differed by less than 5% from those obtained with 4-minute TX scans. The mean differences in perfusion scores between the rapid and 4-minute TX scans were 0.46% (95% confidence interval, −1.84% to 0.93%) at rest and 0.39% (95% confidence interval, −1.84% to 1.07%) at stress, demonstrating equivalency of the rapid and 4-minute scans.

Conclusions
Ordered-subsets expectation maximization with a Bayesian prior accurately and efficiently reconstructs rapidly acquired Ge-68 TX scans for Rb-82 myocardial perfusion positron emission tomography studies.
Relation: 14(5) pp.706-714
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51183
Appears in Collections:[資訊工程學系] 期刊論文

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