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|Title: ||Reconstruction of rapidly acquired Germanium-68 transmission scans for cardiac PET attenuation correction|
|Authors: ||Hsu BL|
|Keywords: ||Cardiac positrom emission tomography|
ordered-subsets expectation maximization with Bayesian prior
|Issue Date: ||2018-11-15T03:27:13Z
|Publisher: ||Journal of nuclear cardiology|
|Abstract: ||Abstract: Background
Transmission (TX) scan time by use of radionuclide sources for cardiac positron emission tomography prolong imaging and increase the likelihood of patient motion artifacts. A reconstruction algorithm combining ordered-subsets expectation maximization with a Bayesian prior was developed and applied to rapid Germanium-68 (Ge-68) TX scans.
Methods and Results
A cardiac phantom with Fluorine-18 (Fl-18) was used to determine a minimal count threshold for Ge-68 TX scanning. Images were acquired over a count range from 2.5 ×106 to 8×107 and for a high-count scan of 1.6×109 counts to study reconstruction parameters and to determine the minimum TX count threshold. The method was compared against clinical 4-minute TX scans in ten Rubidium-82 (Rb-82) rest/stress myocardial perfusion studies (body mass index, 30±4kg/m2). The minimal count threshold was 20×106, and the mean scan time for the Rb-82 studies was 70.5±3.4 seconds. More than 90% of the segmental scores computed from images acquired via rapid TX scans differed by less than 5% from those obtained with 4-minute TX scans. The mean differences in perfusion scores between the rapid and 4-minute TX scans were 0.46% (95% confidence interval, −1.84% to 0.93%) at rest and 0.39% (95% confidence interval, −1.84% to 1.07%) at stress, demonstrating equivalency of the rapid and 4-minute scans.
Ordered-subsets expectation maximization with a Bayesian prior accurately and efficiently reconstructs rapidly acquired Ge-68 TX scans for Rb-82 myocardial perfusion positron emission tomography studies.
|Relation: ||14(5) pp.706-714|
|Appears in Collections:||[資訊工程學系] 期刊論文|
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