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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51178

Title: Diagnostic and clinical benefit of combined coronary calcium and perfusion assessment in patients undergoing PET/CT myocardial perfusion stress imaging
Authors: Bybee KA
Lee J
Markiewicz R
Longmore R
Iain McGhie A
O'Keefe JH
Hsu BL
Kennedy K
Thompson RC
Bateman TM
Contributors: 國立臺灣海洋大學:資訊工程學系
Keywords: PET/CT imaging
atherosclerosis
coronary artery disease
diagnostic and prognostic application
myocardial perfusion
imaging: PET
Date: 2010-04
Issue Date: 2018-11-15T03:00:03Z
Publisher: Journal of nuclear cardiology
Abstract: Abstract: Background
A limitation of stress myocardial perfusion imaging (MPI) is the inability to detect non-obstructive coronary artery disease (CAD). One advantage of MPI with a hybrid CT device is the ability to obtain same-setting measurement of the coronary artery calcium score (CACS).

Methods and Results
Utilizing our single-center nuclear database, we identified 760 consecutive patients with: (1) no CAD history; (2) a normal clinically indicated Rb-82 PET/CT stress perfusion study; and (3) a same-setting CAC scan. 487 of 760 patients (64.1%) had subclinical CAD based on an abnormal CACS. Of those with CAC, the CACS was >100, >400, and >1000 in 47.0%, 22.4%, and 8.4% of patients, respectively. Less than half of the patients with CAC were receiving aspirin or statin medications prior to PET/CT imaging. Patients with CAC were more likely to be initiated or optimized on proven medical therapy for CAD immediately following PET/CT MPI compared to those without CAC.

Conclusions
Subclinical CAD is common in patients without known CAD and normal myocardial perfusion assessed by hybrid PET/CT imaging. Identification of CAC influences subsequent physician prescribing patterns such that those with CAC are more likely to be treated with proven medical therapy for the treatment of CAD.
Relation: 17(2) pp.188-196
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51178
Appears in Collections:[資訊工程學系] 期刊論文

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