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Title: Effect of different treatments on excretion of tetrodotoxin after oral administration in rat
Authors: Hsiao-Chin Jen
Tzu-Chun Lin
Ya-Jung Wu
Yu-Chun Chen
Cheng Hong Hsieh
Deng-Fwu Hwang
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: Tetrodotoxin (TTX)
Date: 2015-04
Issue Date: 2018-11-14T08:45:16Z
Publisher: Journal of Drug Metabolism & Toxicology
Abstract: Abstract: The levels of tetrodotoxin (TTX) in the serum and urine were investigated by using LC-MS method in healthy male wistar rats after oral administration with single dose of 60 nmoleTTX mixture. After treatment, male wistar rats were randomly divided into three groups: (1) rats drink distilled water; (2) rats drink saline solution; (3) rats drink alkaline electrolyzed (AE) water. The serum and urine samples were collected at intervals between 2 hr to 60 hr after orally administration. It was found that TTX can be detected from serum and urine up to 60 hr the max that was tested when intoxicated poisoning occurred. The highest amount of TTX appeared after 4 hr and 6 hr in the serum and urine, respectively. When the rats took AE water, TTX was secreted earlier from the serum and urine. It indicates that AE water enhances the excretion of TTX in the rats. Moreover, LC-MS is useful for detecting TTX in serum and urine samples and may have diagnostic potential for TTX intoxication.
Relation: 6(2)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51154
Appears in Collections:[食品科學系] 期刊論文

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