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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51130

Title: The effects of gamma irradiation sterilization, temperature, and pH on the antimicrobial activity of epinecidin-1
Authors: Huang, Han-ning
Wu, Chang-jer
Chen, Jyh-yih
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: gamma irradiation
antimicrobial peptide
epinecidin-1
methicillin-resistant Staphylococcus aureus (MRSA)
antibacterial activity
Date: 2017-06
Issue Date: 2018-11-13T07:43:06Z
Publisher: Journal of Marine Science and Technology
Abstract: Abstract: This study examined how different processing conditions affected the antibacterial activity of epinecidin-1 alone or in combination with deionized distilled water or KY jelly and evaluated its activity against methicillin resistant Staphylococcus aureus (MRSA) in a product development pipeline. High temperature and γ-irradiation (25 kGy) decreased antimicrobial activity of epinecidin-1, as determined by measuring minimal inhibitory concentrations (MICs) and minimal bactericidal concentrations (MBCs). However, epinecidin-1 exhibited high antimicrobial activity under low pH conditions. The pH stability and the wide spectrum of action against methicillin resistant Staphylococcus aureus (MRSA) may make epinecidin-1 peptide a suitable drug candidate. This research demonstrates the effects of gamma irradiation, temperature, and pH on the antimicrobial activity of epinecidin-1 in a product development pipeline. Its stability at low pH and wide spectrum of action against MRSA make the epinecidin-1 peptide an excellent drug candidate. Epinecidin-1 is effective at repressing the growth of MRSA, and it could be used as a lead for developing new antimicrobial agents against MRSA and related organisms.
Relation: 25(3) pp.352-357
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/51130
Appears in Collections:[食品科學系] 期刊論文

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