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题名: Lactobacillus reuteri induces intestinal immune tolerance against food allergy in mice
作者: Chung-Hsiung Huang
Yu-Chin Lin
Tong-Rong Jan
贡献者: 國立臺灣海洋大學:食品科學系
关键词: Food allergy
Lactobacillus reuteri
Regulatory T cell
Tolerogenic dendritic cell
日期: 2017-04
上传时间: 2018-11-01T03:32:50Z
出版者: Journal of Functional Foods
摘要: Abstract: The effect of Lactobacillus reuteri against food allergy was investigated in ovalbumin (OVA)-sensitized BALB/c mice. Oral administration with L. reuteri restored the deteriorated profile of enteric flora, and attenuated allergic diarrhoea, mast cell activation, and serum IgE production in allergic mice. The production of signature T helper (Th)1 and 2 cytokines, namely IFN-γ and IL-4, by splenocytes was suppressed by L. reuteri. Concordantly, the intestinal expression of IFN-γ, IL-4, T-bet and GATA3 was down-regulated. However, L. reuteri augmented the expression of IL-10, TGF-β and Foxp3, and the number of IL-10-secreting CD11c+CD103+ mesenteric lymph node (MLN) cells. Furthermore, direct exposure to heat-killed L. reuteri attenuated OVA-induced cell proliferation and IL-2 secretion by MLN cells. These results demonstrate that L. reuteri possesses anti-allergic activities via modulating enteric flora and promoting tolerogenic immune responses, and suggest L. reuteri as a functional probiotic against food allergy.
關聯: 31 pp.44-51
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50944
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