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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50578

Title: Toxicological evaluation of low molecular weight fucoidan in Vitro and in Vivo.
Authors: Hwang PA
Yan MD
Lin HT
Li KL
Lin YC
Contributors: 國立臺灣海洋大學:生命科學暨生物科技學系
Keywords: Laminaria japonica
low molecular weight fucoidan
toxicity
Date: 2016-06
Issue Date: 2018-10-16
Publisher: Mar Drugs
Abstract: Abstract: For a long time, fucoidan has been well known for its pharmacological activities, and recently low molecular weight fucoidan (LMF) has been used in food supplements and pharmaceutical products. In the present study, LMF was extracted from Laminaria japonica by enzyme hydrolysis. The toxicity of LMF in mouse and rat models was determined by many methods, such as total arsenic content, bacterial reverse mutation assay, chromosome aberration assay, and in vivo micronucleus assay. The present findings showed that LMF at 5000 μg/mL exhibited no mutagenicity. It also produced no formatting disruption of red blood cells in vivo. At 2000 mg/kg BW/day there were no toxicological indications. LMF is expected to be used as a safe food supplement.
Relation: 14(7)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50578
Appears in Collections:[生命科學暨生物科技學系] 期刊論文

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