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Title: Neuroprotective effects of the lipidic extract from integument of squid Dosidicus gigas
Authors: Hwang, P. A
Tsai, Y. G
Gau, S. Y
Hung, Y. L
Fan, C. C
Contributors: 國立臺灣海洋大學:生命科學暨生物科技學系
Date: 2011-02
Issue Date: 2018-10-15T08:54:43Z
Publisher: Journal of Marine Science and Technology
Abstract: Abstract: The integument of the squid Dosidicus gigas is an industrial waste and trouble the industrial processing. In this study, we examined the lipid composition and neuroprotective effects of D. gigas integument lipidic extract (DGI) in SH-SY5Y neuro-blastoma cells which have been exposed to H 2 O 2 . The results showed that phospholipids, triacylglycerol and cholesterol accounted for 70.90 ± 4.96 (mean ± S.D.), 20.70 ± 3.54 and 8.40 ± 0.28% of DGI, respectively. And the main fatty acids were docosahexaenoic acid (30.53% of total fatty acid), pal-mitic acid (20.36% of total fatty acid) and eicosapentaenoic acid (11.84% of total fatty acid). DGI at the concentrations of 2, 4 and 8 mg/ml successfully protected SH-SY5Y cells against the cytotoxicity, markedly increased the cell proliferation, an-tioxidant enzymes of glutathione contents and catalase activi-ties, and inhibited the secretion of amyloid β-peptide 1-42. Our results suggested that DGI may be a possible approach in the prevention of Alzheimer's disease and other neurodegen-erative diseases.
Relation: 19(1) pp.101-106
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50577
Appears in Collections:[生命科學暨生物科技學系] 期刊論文

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