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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50471

Title: xUBF, an RNA polymerase I transcription factor, binds crossover DNA with low sequence specificity.
Authors: Hu CH
McStay B
Jeong SW
Reeder RH
Contributors: 國立臺灣海洋大學:生命科學暨生物科技學系
Date: 1994-05
Issue Date: 2018-10-09T03:07:42Z
Publisher: Mol Cell Biol
Abstract: Abstract: Xenopus UBF (xUBF) is a transcription factor for RNA polymerase I which contains multiple DNA-binding motifs. These include a short basic region adjacent to a dimer motif plus five high-mobility-group (HMG) boxes. All of these DNA-binding motifs exhibit low sequence specificity, whether assayed singly or together. In contrast, the HMG boxes recognize DNA structure that is formed when two double helices are crossed over each other. HMG box 1, in particular, requires association of two double helices before it will bind and, either by itself or in the context of the intact protein, will loop DNA and organize it into higher-order structures. We discuss how this mode of binding affects the function of xUBF as a transcription factor.
Relation: 14(5) pp.2871-2882
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50471
Appears in Collections:[生命科學暨生物科技學系] 期刊論文

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