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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50342

Title: A sensitive bithiophene-based biosensor for interferon-gamma characterization and analysis
Authors: P. I. Tsai
S. S. Lee
S. T. Chou
C. M. Jan
Y. T. Chang
A. S. Y. Lee
C. K. Lee
Contributors: 國立臺灣海洋大學:系統工程暨造船學系
Keywords: Surface plasmon resonance
Ellipsometry
Interferon-gamma
Phase-interrogation
Bithiophene
Date: 2014-11
Issue Date: 2018-10-05T01:15:43Z
Publisher: Thin Solid Films
Abstract: Abstract: Real-time, label-free monitoring offers a wide range of applications to the biotech field. We developed an integrated bio-sensing platform which adapts a circular polarization interferometry configuration and a phase modulated ellipsometer to improve the performance of biomolecular measurements. An bithiophene-based conductive linker-5′-(mercapto)-[2, 2′-bithiophene]-5-carboxylic acid was developed for detecting antibody–antigen interactions. In this study, the biomarker interferon-gamma (IFN-γ), one of the most important indicators of tuberculosis, was chosen to test and verify the sensitivity of our measurement system. Our experimental results showed that an increase in the concentration of the IFN-γ (64 pM to 1 μM) was usually accompanied by a phase increase. This result is good evidence that our biosensing system can be useful for analyzing biomolecular interactions.
Relation: 571 pp.473-477
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50342
Appears in Collections:[系統工程暨造船學系] 期刊論文

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