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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50322

Title: Manufacturing Process Technology of Dual-wavelength Laser Direct-write Nanolithography System for Gold-nanoparticle-based Localized Surface Plasma Resonance Biosensor
Authors: Hsing-Cheng Yu
Shuen-Chen Chen
Ding-Zheng Lin
Contributors: 國立臺灣海洋大學:系統工程暨造船學系
Keywords: biosensor
dual wavelength
localized surface plasma resonance
Date: 2018-02
Issue Date: 2018-10-04T02:04:49Z
Publisher: Sensors and Materials
Abstract: Abstract: Recently, in vitro diagnostics (IVD) has been widely applied in the qualitative and quantitative analyses of medical diagnoses and drug development in biomedical technology. There are ~50% global IVD markets including immunoassay, molecular diagnostics, point-of-care testing, and biosensor detection. Therefore, the development of a manufacturing process technology for biosensor detection that is cost-effective and highly sensitive is important. In general, the biochip development of metal nanostructure arrays adopting localized surface plasma resonance (LSPR) is based on mechanical nanolithography with a tip of an atomic force microscope. However, it does not improve the irregular shapes and dimensions during the mass production of biochips, and does not increase the process area, so sensitivity is sacrificed. In this paper, we present a novel dual-wavelength laser direct-write nanolithography system for fabricating periodic gold nanoparticle arrays on substrates for biosensors. The substrates were immersed by a wet etching method after exposure. Isotropic etching using oxygen-plasma method transfer to the substrates was then performed to fabricate a suitable undercut in the liftoff of the dry etching process. The pitch, depth, and width of the periodic gold nanoparticle arrays were 500, 43, and 197 nm, respectively, and the measured transmission spectrum was 800 nm. Chips based on the periodic gold nanoparticle arrays were designed for LSPR biosensors with high sensitivity, to be widely applied in biomedical fields.
Relation: 30(3) pp.355-363
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50322
Appears in Collections:[系統工程暨造船學系] 期刊論文

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