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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50279

Title: The migration speed of cancer cells influenced by macrophages and myofibroblasts co-cultured in a microfluidic chip.
Authors: T.H. Hsu
Y.L. Kao
W.L. Lin
J.L. Xiao
P.L. Kuo
C.W. Wu
W.Y. Liao
C.H. Lee
Contributors: 國立臺灣海洋大學:機械與機電工程學系
Date: 2012-02
Issue Date: 2018-09-28T05:53:47Z
Publisher: Integrative Biology
Abstract: Abstract: We employ a microfluidic chip with three culture chambers to investigate the interactions among lung cancer cells, macrophages and myofibroblasts. By mixing the conditioned media of macrophages and myofibroblasts in this chip, we confirm that these two stromal cells have synergistic effects in accelerating the migration of cancer cells. However, as the myofibroblasts are pretreated with the conditioned medium of macrophages, the myofibroblasts' ability to enhance the migration of cancer cells is lowered. The tumour necrosis factor-α produced by macrophages reduces the expression of α-smooth muscle actin and the secretion of transforming growth factor-β1 in myofibroblasts. Once the tumour necrosis factor-α in the macrophage conditioned medium is neutralized, the macrophage medium-pretreated myofibroblasts can still accelerate the migration of cancer cells.
Relation: 4(2) pp.177-182
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/50279
Appears in Collections:[機械與機電工程學系] 期刊論文

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