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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47446

Title: Conjugation of γ-Fe2O3 nanoparticles with single strand oligonucleotides
Authors: Y.D. Yao
C.W. Lee
K.T. Huang
P.K. Wei
Contributors: 國立臺灣海洋大學:光電科學研究所
Keywords: Protein
Nanoparticle
Oligonucleotide
Date: 2006-03
Issue Date: 2018-07-23T03:38:08Z
Publisher: JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS
Abstract: Abstract: Following the thermodecomposition synthetic route, water soluble γ-Fe2O3 nanoparticles have been successfully prepared, with average size 8.8±1.3 nm. Based on the process we developed, the magnetic particles have carboxyl group on their surfaces. By using 1-ethyl-3-(3-dimrthylaminopropyl)carbodiimide hydrochloride [EDC] as a liker reagent, we successfully modified a protein, streptavidin, on the surface of γ-Fe2O3 nanoparticles. With the strong affinity between biotin with streptavidin, we could use the streptavidin-modified magnetic nanoparticles to separate the rare biotin functionalized molecules from the mixed solution. On the other hand, streptavidin functionalized Fe2O3 can catch a biotin labeled single strand oligonucleotides through the strong affinity between streptavidin and biotin. The oligonucleotides functionalized magnetic nanoparticle would separate a specific oligonucleotide from a mixture. This design may be used to create a technique to detect diseases in the future.
Relation: 304(1) pp.412-414
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47446
Appears in Collections:[光電科學研究所] 期刊論文

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