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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47425

Title: Intensity sensitivity of gold nanostructures and its application for high-throughput biosensing
Authors: Pei-Kuen Wei
Kuang-Li Lee
Shu-Han Wu
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2009-11
Issue Date: 2018-07-18T08:03:12Z
Publisher: Optics Express
Abstract: Abstract: A new microarray for dynamical studies of surface biomolecular interactions without fluorescent labeling is proposed. We employed gold nanostructures to excite surface plasmons on the microarray surface and detected the intensity changes in the extraordinary transmission. The calculation and measurement results indicate that the nanoslit array has an intensity sensitivity much higher than the nanohole array due to its narrower resonant bandwidth. In addition, the sensitivity is increased as the slit width decreases. For 35 nm slit width, the intensity sensitivity reaches to ~4000%/RIU, two times larger than the slit width larger than 150 nm. Using the intensity changes, we demonstrate a 10 × 10 microarray for real-time measurements of antigen-antibody and DNA-DNA interactions.
Relation: 17(25) pp.23104-23113
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47425
Appears in Collections:[光電科學研究所] 期刊論文

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