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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47364

Title: Highly Sensitive Aluminum-Based Biosensors using Tailorable Fano Resonances in Capped Nanostructures
Authors: Pei-Kuen Wei
Kuang-Li Lee
Hsuan-Yeh Hsu
Meng-Lin You
Chia-Chun Chang
Ming-Yang Pan
Xu Shi
Hiroaki Misawa
Kosei Ueno
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2017-03
Issue Date: 2018-07-17T01:55:47Z
Publisher: Scientific Reports
Abstract: Abstract: Metallic nanostructure-based surface plasmon sensors are capable of real-time, label-free, and multiplexed detections for chemical and biomedical applications. Recently, the studies of aluminum-based biosensors have attracted a large attention because aluminum is a more cost-effective metal and relatively stable. However, the intrinsic properties of aluminum, having a large imaginary part of the dielectric function and a longer evanescent length, limit its sensing capability. Here we show that capped aluminum nanoslits fabricated on plastic films using hot embossing lithography can provide tailorable Fano resonances. Changing height of nanostructures and deposited metal film thickness modulated the transmission spectrum, which varied from Wood’s anomaly-dominant resonance, asymmetric Fano profile to surface plasmon-dominant resonance. For biolayer detections, the maximum surface sensitivity occurred at the dip of asymmetric Fano profile. The optimal Fano factor was close to −1.3. The wavelength and intensity sensitivities for surface thickness were up to 2.58 nm/nm and 90%/nm, respectively. The limit of detection (LOD) of thickness reached 0.018 nm. We attributed the enhanced surface sensitivity for capped aluminum nanoslits to a reduced evanescent length and sharp slope of the asymmetric Fano profile. The protein-protein interaction experiments verified the high sensitivity of capped nanostructures. The LOD was down to 236 fg/mL.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47364
Appears in Collections:[光電科學研究所] 期刊論文

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