National Taiwan Ocean University Institutional Repository:Item 987654321/47361
English  |  正體中文  |  简体中文  |  全文筆數/總筆數 : 27454/39300
造訪人次 : 2533797      線上人數 : 30
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜尋範圍 進階搜尋

請使用永久網址來引用或連結此文件: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47361

題名: Chip-based digital surface plasmon resonance sensing platform for ultrasensitive biomolecular detection
作者: Pei-Kuen Wei
Ming-Yang Pan
Kuang-Li Lee
Likarn Wang
日期: 2017-05
上傳時間: 2018-07-17T01:40:08Z
出版者: Biosensors and Bioelectronics
摘要: Abstract: A chip-based ultrasensitive surface plasmon resonance (SPR) sensor in a checkerboard nanostructure on plastic substrates is presented for digital detection. The sensing elements on the checkerboard are composed of silver-capped nanoslit arrays, which were fabricated using the thermal-embossing nanoimprint method, to meet the demand for low-cost and rapid fabrication. Sharp Fano resonances in the optimized nanoslit arrays provide high-intensity sensitivities (20,000% per refractive index unit), with an element size of 12.5 µm. The polarization-dependent transmission in the checkerboard pattern produces optical isolation between sensing elements and results in a crosstalk lower than 1%. Protein–antibody experiments demonstrated that the digital detection limit was up to 1 pg/mL, which is approximately 1000 times lower than that of conventional analog detection. For a 140 µm×140 µm checkerboard pattern, the dynamic range was approximately 100 times higher than that of conventional surface plasmon resonance measurements. This new digital detection method is very useful for detecting ultralow concentrations of analytes with a nonuniform distribution on the sensor surface.
關聯: 91(15) pp.580-587
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47361
顯示於類別:[光電科學研究所] 期刊論文

文件中的檔案:

檔案 描述 大小格式瀏覽次數
index.html0KbHTML27檢視/開啟


在NTOUR中所有的資料項目都受到原著作權保護.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回饋