English  |  正體中文  |  简体中文  |  Items with full text/Total items : 26994/38795
Visitors : 2388995      Online Users : 54
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
LoginUploadHelpAboutAdminister

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47361

Title: Chip-based digital surface plasmon resonance sensing platform for ultrasensitive biomolecular detection
Authors: Pei-Kuen Wei
Ming-Yang Pan
Kuang-Li Lee
Likarn Wang
Date: 2017-05
Issue Date: 2018-07-17T01:40:08Z
Publisher: Biosensors and Bioelectronics
Abstract: Abstract: A chip-based ultrasensitive surface plasmon resonance (SPR) sensor in a checkerboard nanostructure on plastic substrates is presented for digital detection. The sensing elements on the checkerboard are composed of silver-capped nanoslit arrays, which were fabricated using the thermal-embossing nanoimprint method, to meet the demand for low-cost and rapid fabrication. Sharp Fano resonances in the optimized nanoslit arrays provide high-intensity sensitivities (20,000% per refractive index unit), with an element size of 12.5 µm. The polarization-dependent transmission in the checkerboard pattern produces optical isolation between sensing elements and results in a crosstalk lower than 1%. Protein–antibody experiments demonstrated that the digital detection limit was up to 1 pg/mL, which is approximately 1000 times lower than that of conventional analog detection. For a 140 µm×140 µm checkerboard pattern, the dynamic range was approximately 100 times higher than that of conventional surface plasmon resonance measurements. This new digital detection method is very useful for detecting ultralow concentrations of analytes with a nonuniform distribution on the sensor surface.
Relation: 91(15) pp.580-587
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47361
Appears in Collections:[光電科學研究所] 期刊論文

Files in This Item:

File Description SizeFormat
index.html0KbHTML25View/Open


All items in NTOUR are protected by copyright, with all rights reserved.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback