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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47350

Title: Synchrotron microradiography study on acute lung injury of mouse caused byPM2.5 aerosols
Authors: Pei-Chebg
Yongpeng Tong
Guilin Zhang
Yan Li
Mingguan Tan
Wei Wang
Jianmin Chen
Yeukuang Hwu
Contributors: 國立臺灣海洋大學:光電科學研究所
Keywords: CIBM-PC
synchrotron microradiography
lung injury
Date: 2005-11
Issue Date: 2018-07-16T08:13:16Z
Publisher: European Journal of Radiology
Abstract: Abstract: In order to investigate FeSO4, ZnSO4 (the two of main metal compositions of Shanghai PM2.5 (particle matter with those aerodynamical diameter <2.5 mu m)) effects on acute lung injury, six solutions contained PM2.5 aerosol particles, FeSO4, ZnSO4 and their mixtures were instilled intratracheally into mouse lungs for experiment. By 2 days. after instillation, the live mice were checked in vivo by synchrotron refractive index microradiography. In addition after extracted and examined by dissection, the right lobes of lung were fixed by formalin, then imaged by synchrotron microradiography again. Corresponding parts of those lung tissues were embedded in paraffin for histopathologic study. The synchrotron X-ray microradiographs of live mouse lung showed different lung texture changes after instilled with different toxic solutions. Hemorrhage points in lung were observed more from those mice instilled by FeSO4 contained toxin solutions groups. Bronchial epithelial hyperplasia can be observed in ZnSO4 contained solution-instilled groups from histopathologic analysis. It was found that the acute lung injury of mice caused by solution of PM2.5 + FeSO4 + ZnSO4 was more serious than other toxin solutions. Results suggested that FeSO4 mainly induced hemorrhage and ZnSO4 mainly induced inflammation and bronchiolar epithelial hyperplasia in the early toxicological effects of PM2.5 (C) 2005 Elsevier Ireland Ltd. All rights reserved.
Relation: 58(2) pp.266-272
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47350
Appears in Collections:[光電科學研究所] 期刊論文

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