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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47328

Title: The Serpin SPN5 Is Essential For Wing Expansion In Drosophila Melanogaster
Authors: Jean-Dominique Vassalli
Yves Charron
Rime Madani
Chantal Combepine
Vincent Gajdosik
Yeukuang Hwu
Giorgio Margaritondo
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2008-07
Issue Date: 2018-07-16T03:34:12Z
Abstract: Abstract: Serpins, a superfamily of protease inhibitors, control proteolytic cascades in many physiological processes. Genomic studies have revealed the presence of a high number of serpin-encoding genes in Drosophila melanogaster, but their functions remain largely unknown. In a biochemical screen designed to detect protease inhibitors that may be implicated in early Drosophila development, we identified in embryos a ligand that forms a 67 kDa SDS-stable complex with the broad spectrum protease trypsin. Characterization of this ligand revealed it to be the recently described serpin, Spn5. Expression analysis by in situ and Northern blot hybridization indicated maternal transmission of the transcript as well as zygotic expression in many larval, pupal and adult tissues. Targeted repression by RNA interference did not alter early embryogenesis but resulted in a complete defect in the unfolding and expansion of the wings of freshly eclosed mutant flies, without other detectable effects on development.
Relation: 52(7)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47328
Appears in Collections:[光電科學研究所] 期刊論文

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