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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47312

Title: Biosensing, Cytotoxicity, and Cellular Uptake Studies of Surface-Modified Gold Nanorods
Authors: Yeu-Kuang Hwu
Harshala J. Parab
Hao Ming Chen
Tsung-Ching Lai
Jing Hong Huang
Po Hsun Chen
Ru-Shi Liu
Michael Hsiao
Chung-Hsuan Chen
Din-Ping Tsai
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2009-04
Issue Date: 2018-07-16T02:00:34Z
Publisher: Journal of Physical Chemistry C
Abstract: Abstract: Herein we report biorecognition studies of protein IgG using biocomapatible gold nanorods as molecular probes. Surface modification of cetyltrimethylammonium bromide (CTAB)-stabilized gold nanorods was carried out by using poly(styrenesulfonate) (PSS) to reduce the toxicity of as-synthesized gold nanorods caused by free CTAB. ζ potential analysis confirmed charge reversal on the surface of gold nanorods caused by the PSS coating. Surface plasmon resonance exhibited by gold nanorods has been employed as a tool for analyzing the binding events for biomolecules. TEM results, showing the aggregation of gold nanorods, in addition to the shift in surface plasmon resonance peak in UV−vis absorption measurements, upon the interaction of biomolecules with gold nanorods, confirmed molecular binding. Morphological changes caused by the cellular uptake of gold nanorods before and after PSS modification have been observed. Cell viability studies using gold nanorods were performed to study the cytotoxic effects of these molecular probes.
Relation: 113(18) pp.7574–7578
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47312
Appears in Collections:[光電科學研究所] 期刊論文

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