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Title: Enhancement of irradiation effects on cancer cells by cross-linked dextran-coated iron oxide (CLIO) nanoparticles
Authors: Tzu-En Hua, Y
Fu-Kuo Huang
Wen-Chang Chen
Sheng-Feng Lai
Chi-Jen Liu
Cheng-Liang Wang
Chang-Hai Wang
Hsiang-Hsin Chen
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2010-01
Issue Date: 2018-07-16
Abstract: Abstract: We investigated iron oxide nanoparticles with two different surface modifications, dextran coating and cross-linked dextran coating, showing that their different internalization affects their capability to enhance radiation damage to cancer cells. The internalization was monitored with an ultrahigh resolution transmission x-ray microscope (TXM), indicating that the differences in the particle surface charge play an essential role and dominate the particle-cell interaction. We found that dextran-coated iron oxide nanoparticles cannot be internalized by HeLa and EMT-6 cells without being functionalized with amino groups (the cross-linked dextran coating) that modify the surface potential from -18 mV to 13.4 mV. The amount of cross-linked dextran-coated iron oxide nanoparticles uptaken by cancer cells reached its maximum, 1.33 x 10(9) per HeLa cell, when the co-culture concentration was 40 microg Fe mL(-1) or more. Standard tests indicated that these internalized nanoparticles increased the damaging effects of x-ray irradiation, whereas they are by themselves biocompatible. These results could lead to interesting therapy applications; furthermore, iron oxide also produces high contrast for magnetic resonance imaging (MRI) in the diagnosis and therapy stages.
Relation: 55(2)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47297
Appears in Collections:[光電科學研究所] 期刊論文

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