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题名: Enhancement of Cell Radiation Sensitivity by Pegylated Gold Nanoparticles
作者: Y Hwu
Chi-Jen Liu
Chang-Hai Wang
Shin-Tai Chen
Hsiang-Hsin Chen
Wei-Hua Leng
Chia-Chi Chien
Cheng-Liang Wang
贡献者: 國立臺灣海洋大學:光電科學研究所
日期: 2010-02
上传时间: 2018-07-10T03:50:02Z
摘要: Abstract: Biocompatible Au nanoparticles with surfaces modified by PEG (polyethylene glycol) were developed in view of possible applications for the enhancement of radiotherapy. Such nanoparticles exhibit preferential deposition at tumor sites due to the enhanced permeation and retention (EPR) effect. Here, we systematically studied their effects on EMT-6 and CT26 cell survival rates during irradiation for a dose up to 10 Gy with a commercial biological irradiator (E(average) = 73 keV), a Cu-Kalpha(1) x-ray source (8.048 keV), a monochromatized synchrotron source (6.5 keV), a radio-oncology linear accelerator (6 MeV) and a proton source (3 MeV). The percentage of surviving cells after irradiation was found to decrease by approximately 2-45% in the presence of PEG-Au nanoparticles ([Au] = 400, 500 or 1000 microM). The cell survival rates decreased as a function of the dose for all sources and nanoparticle concentrations. These results could open the way to more effective cancer irradiation therapies by using nanoparticles with optimized surface treatment. Difficulties in applying MTT assays were also brought to light, showing that this approach is not suitable for radiobiology.
關聯: 55(4)
显示于类别:[光電科學研究所] 期刊論文


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