National Taiwan Ocean University Institutional Repository:Item 987654321/47294
English  |  正體中文  |  简体中文  |  全文笔数/总笔数 : 28595/40626
造访人次 : 4205533      在线人数 : 38
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
搜寻范围 进阶搜寻

jsp.display-item.identifier=請使用永久網址來引用或連結此文件: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47294

题名: Enhancement of Cell Radiation Sensitivity by Pegylated Gold Nanoparticles
作者: Y Hwu
Chi-Jen Liu
Chang-Hai Wang
Shin-Tai Chen
Hsiang-Hsin Chen
Wei-Hua Leng
Chia-Chi Chien
Cheng-Liang Wang
贡献者: 國立臺灣海洋大學:光電科學研究所
日期: 2010-02
上传时间: 2018-07-10T03:50:02Z
出版者: PHYSICS IN MEDICINE AND BIOLOGY
摘要: Abstract: Biocompatible Au nanoparticles with surfaces modified by PEG (polyethylene glycol) were developed in view of possible applications for the enhancement of radiotherapy. Such nanoparticles exhibit preferential deposition at tumor sites due to the enhanced permeation and retention (EPR) effect. Here, we systematically studied their effects on EMT-6 and CT26 cell survival rates during irradiation for a dose up to 10 Gy with a commercial biological irradiator (E(average) = 73 keV), a Cu-Kalpha(1) x-ray source (8.048 keV), a monochromatized synchrotron source (6.5 keV), a radio-oncology linear accelerator (6 MeV) and a proton source (3 MeV). The percentage of surviving cells after irradiation was found to decrease by approximately 2-45% in the presence of PEG-Au nanoparticles ([Au] = 400, 500 or 1000 microM). The cell survival rates decreased as a function of the dose for all sources and nanoparticle concentrations. These results could open the way to more effective cancer irradiation therapies by using nanoparticles with optimized surface treatment. Difficulties in applying MTT assays were also brought to light, showing that this approach is not suitable for radiobiology.
關聯: 55(4)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47294
显示于类别:[光電科學研究所] 期刊論文

文件中的档案:

档案 描述 大小格式浏览次数
index.html0KbHTML27检视/开启


在NTOUR中所有的数据项都受到原著作权保护.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - 回馈