English  |  正體中文  |  简体中文  |  Items with full text/Total items : 27228/39071
Visitors : 2410695      Online Users : 70
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search
LoginUploadHelpAboutAdminister

Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47290

Title: In situ real-time investigation of cancer cell photothermolysis mediated by excited gold nanorod surface plasmons
Authors: Su-Jien
Cheng-Lung Chen
Ling-Ru Kuo
Ching-Lin Chang
Yeu-Kuang Hwu
Cheng-Kuang Huang
Shin-Yu Lee
Kowa Chen
Contributors: 國立臺灣海洋大學:光電科學研究所
Keywords: Fluorescence
Gold
Plasma
Membrane
Laser
Date: 2010-05
Issue Date: 2018-07-10T03:19:37Z
Publisher: BIOMATERIALS
Abstract: Abstract: The photothermolysis of living EMT-6 breast tumor cells triggered by gold nanorods (AuNRs) with two-photon irradiation was conducted in situ and under real-time observation. The morphology and plasma membrane permeability of the cells were key indicators to the phenomena. AuNRs with an aspect ratio of 3.92, and a longitudinal absorption peak at 800 nm were synthesized with a seed-mediated method. The nanorods surfaces were further modified with polystyrenesulfonate (PSS) for biocompatibility. The prepared nanorods displayed excellent two-photon photoluminescence imaging. In situ real-time results revealed cavities internal to the cells were created from thermal explosions triggered by AuNRs localized photothermal effect. The cavitation dynamic is energy dependent and responsible for the perforation or sudden rupture of the plasma membrane. The energy threshold for cell therapy depended significantly on the number of nanorods taken up per cell. For an ingested AuNR cluster quantity N ∼ 10–30 per cell, it is found that energy fluences E larger-than 93 mJ/cm2 led to effective cell destruction in the crumbled form within a very short period. As for a lower energy level E = 18 mJ/cm2 with N ∼ 60–100, a non-instant, but progressive cell deterioration, is observed.
Relation: 31(14) pp.4104-4112
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47290
Appears in Collections:[光電科學研究所] 期刊論文

Files in This Item:

File Description SizeFormat
index.html0KbHTML13View/Open


All items in NTOUR are protected by copyright, with all rights reserved.

 


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback