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题名: X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors
作者: G. Margaritondo
Chang-Hai Wang
Chi-Jen Liu
Chia-Chi Chien
Hsin-Tai Chen
Tzu-En Hua
Wei-Hua Leng
Hsiang-Hsin Chen
Ivan M. Kempson
Y. Hwu
Michael Hsiao
Tsung-Ching Lai
J. L. Wang
Chung-Shi Yang
Hong-Ming Lin
Yu-Jen Chen
贡献者: 國立臺灣海洋大學:光電科學研究所
关键词: X-ray microscopy
Nanoparticle
Biomaterials
Electron microscopy
日期: 2011-03
上传时间: 2018-07-10T01:57:07Z
出版者: MATERIALS CHEMISTRY AND PHYSICS
摘要: Abstract: The spatial distribution of X-ray synthesized, PEG coated Au nanoparticles in cancer-bearing mice and their time dependent accumulation were investigated with inductive coupled plasma – optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM) and histological imaging. The results conclusively demonstrate that the particles strongly accumulate in tumor regions; up to ∼25 times more than in normal muscle tissue. This accumulation increases with the time after injection for up to ∼12 h in tumor, spleen and liver tissues, whereas for most non-tumor regions it saturates or decreases (blood, lung, brain, heart, and kidney). The impact of this result is discussed with special emphasis on passive targeted drug delivery and could also be used for the delineation and early-stage imaging of small tumors.
關聯: 126(1–2) pp.352-356
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47280
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