National Taiwan Ocean University Institutional Repository:Item 987654321/47280
English  |  正體中文  |  简体中文  |  Items with full text/Total items : 28611/40652
Visitors : 754557      Online Users : 50
RC Version 4.0 © Powered By DSPACE, MIT. Enhanced by NTU Library IR team.
Scope Adv. Search

Please use this identifier to cite or link to this item:

Title: X-ray synthesized PEGylated (polyethylene glycol coated) gold nanoparticles in mice strongly accumulate in tumors
Authors: G. Margaritondo
Chang-Hai Wang
Chi-Jen Liu
Chia-Chi Chien
Hsin-Tai Chen
Tzu-En Hua
Wei-Hua Leng
Hsiang-Hsin Chen
Ivan M. Kempson
Y. Hwu
Michael Hsiao
Tsung-Ching Lai
J. L. Wang
Chung-Shi Yang
Hong-Ming Lin
Yu-Jen Chen
Contributors: 國立臺灣海洋大學:光電科學研究所
Keywords: X-ray microscopy
Electron microscopy
Date: 2011-03
Issue Date: 2018-07-10T01:57:07Z
Abstract: Abstract: The spatial distribution of X-ray synthesized, PEG coated Au nanoparticles in cancer-bearing mice and their time dependent accumulation were investigated with inductive coupled plasma – optical emission spectroscopy (ICP-OES), transmission electron microscopy (TEM) and histological imaging. The results conclusively demonstrate that the particles strongly accumulate in tumor regions; up to ∼25 times more than in normal muscle tissue. This accumulation increases with the time after injection for up to ∼12 h in tumor, spleen and liver tissues, whereas for most non-tumor regions it saturates or decreases (blood, lung, brain, heart, and kidney). The impact of this result is discussed with special emphasis on passive targeted drug delivery and could also be used for the delineation and early-stage imaging of small tumors.
Relation: 126(1–2) pp.352-356
Appears in Collections:[Institute of Optoelectronic Sciences] Periodical Articles

Files in This Item:

File Description SizeFormat

All items in NTOUR are protected by copyright, with all rights reserved.


著作權政策宣告: 本網站之內容為國立臺灣海洋大學所收錄之機構典藏,無償提供學術研究與公眾教育等公益性使用,請合理使用本網站之內容,以尊重著作權人之權益。
網站維護: 海大圖資處 圖書系統組
DSpace Software Copyright © 2002-2004  MIT &  Hewlett-Packard  /   Enhanced by   NTU Library IR team Copyright ©   - Feedback