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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47279

Title: Imaging the Cellular Uptake of Tiopronin-modified Gold Nanoparticles
Authors: G. Margaritondo
Xiaoqing Cai
Hsiang-Hsin Chen
Cheng-Liang Wang
Shin-Tai Chen
Sheng-Feng Lai
Chia-Chi Chien
Yi-Yun Chen
Ivan M. Kempson
Y Hwu
C. S. Yang
Contributors: 國立臺灣海洋大學:光電科學研究所
Keywords: Transmission X-ray microscopy
Gold nanoparticles
X-ray synthesis
Cellular uptake
Date: 2011-03
Issue Date: 2018-07-10T01:41:00Z
Publisher: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Abstract: Abstract: Well-dispersed gold nanoparticles (NP) coated with tiopronin were synthesized by X-ray irradiation without reducing agents. High-resolution transmission electron microscopy shows that the average core diameters of the NPs can be systematically controlled by adjusting the tiopronin to Au mole ratio in the reaction. Three methods were used to study the NP uptake by cells: quantitative measurements by inductively coupled plasma mass spectrometry, direct imaging with high lateral resolution transmission electron microscopy and transmission X-ray microscopy. The results confirmed that the NP internalization mostly occurred via endocytosis and concerned the cytoplasm. The particles, in spite of their small sizes, were not found to arrive inside the cell nuclei. The synthesis without reducing agents and solvents increased the biocompatibility as required for potential applications in analysis and biomedicine in general.
Relation: 401(3) pp.809–816
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47279
Appears in Collections:[光電科學研究所] 期刊論文

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