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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47270

Title: Functional histology of glioma vasculature by FTIR imaging
Authors: Petibois C
Noreen R
Pineau R
Chien CC
Cestelli-Guidi M
Hwu Y
Moenner M
Marcelli A
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2011-08
Issue Date: 2018-07-09T08:02:15Z
Publisher: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Abstract: Abstract: Fourier-transform infrared (FTIR) imaging has been used to investigate brain tumor angiogenesis using a mice solid tumor model and bare-gold (∅ 25 nm) or BaSO(4) (∅ 500 nm) nanoparticles (NP) injected into blood vasculature. FTIR images of 20-μm-thick tissue sections were used for chemical histology of healthy and tumor areas. Distribution of BaSO(4)-NP (using the 1,218-1,159 cm(-1) spectral interval) revealed clearly all details of blood vasculature with morphological abnormalities of tumor capillaries, while Au-NP (using the 1,046-1,002 cm(-1) spectral interval) revealed also diffusion properties of leaky blood vessels. Diffusion of Au-NP out of vascular space reached 64 ± 29 μm, showing the fenestration of "leaky" tumor blood vessels, which should allow small NP (<100 nm, as for Au-NP) to diffuse almost freely, while large NP should not (as for BaSO(4)-NP in this study). Therefore, we propose to develop FTIR imaging as a convenient tool for functional molecular histology imaging of brain tumor vasculature, both for identifying blood capillaries and for determining the extravascular diffusion space offered by vessel fenestration.
Relation: 401(3) pp.795-801
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47270
Appears in Collections:[光電科學研究所] 期刊論文

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