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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47269

Title: Detection of collagens in brain tumors based on FTIR imaging and chemometrics”, Anal. Bioanal. Chem
Authors: Cyril Petibois
Razia Noreen
Chia-Chi Chien
Maylis Delugin
Seydou Yao
Raphael Pineau
Yeukuang Hwu
Michel, Moenner
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2011-08
Issue Date: 2018-07-09T07:57:24Z
Publisher: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Abstract: Abstract: Fourier transform infrared (FTIR) imaging has been used as a molecular histopathology tool on brain tissue sections after intracranial implantation and development of glioma tumors. Healthy brain tissue (contralateral lobe) as well as solid and diffuse tumor tissues were compared for their collagen contents. IR spectra were extracted from IR images for determining the secondary structure of protein contents and compared to pure product spectra of collagens (types I, III, IV, V, and VI). Multivariate statistical analyses of variance and correspondence factorial analysis were performed to differentiate healthy and tumor brain tissues as well as their classification according to their secondary structure profiles. Secondary structure profiles revealed that no collagen was present in healthy tissues; they are also significantly different from solid and diffuse tumors (p < 0.05). Solid and diffuse tumors could be discriminated with respect to the secondary structure profile of fibrillar and non-fibrillar collagens, respectively. We can thus propose to develop FTIR imaging for histopathology examination of tumors on the basis of collagen contents.
Relation: 401(3) pp.845–852
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47269
Appears in Collections:[光電科學研究所] 期刊論文

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