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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47268

Title: Detecting small lung tumors in mouse models by refractive-index microradiology
Authors: G. Margaritondo
Chia-Chi Chien
Guilin Zhang
Y. Hwu, Ping Liu
Weisheng Yue
Jianqi Sun
Yan Li
Hongjie Xue
Lisa X Xu
Chang Hai Wang
Nanyow Chen
Chien Hung Lu
Ting-Kuo Lee
Yuh-Cheng Yang
Yen-Ta Lu
Yu-Tai Ching
T. F. Shih
P. C. Yang
J. H. Je
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2011-08
Issue Date: 2018-07-09T07:50:47Z
Publisher: ANALYTICAL AND BIOANALYTICAL CHEMISTRY
Abstract: Abstract: Refractive-index (phase-contrast) radiology was able to detect lung tumors less than 1 mm in live mice. Significant micromorphology differences were observed in the microradiographs between normal, inflamed, and lung cancer tissues. This was made possible by the high phase contrast and by the fast image taking that reduces the motion blur. The detection of cancer and inflammation areas by phase contrast microradiology and microtomography was validated by bioluminescence and histopathological analysis. The smallest tumor detected is less than 1 mm(3) with accuracy better than 1 × 10(-3) mm(3). This level of performance is currently suitable for animal studies, while further developments are required for clinical application.
Relation: 401(3)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47268
Appears in Collections:[光電科學研究所] 期刊論文

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