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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47264

Title: Altered branching patterns of Purkinje cells in mouse model for cortical development disorder,
Authors: Im Joo Rhyu
Jinkyung Kim
Namseop Kwon
Soeun Chang
Kyong-Tai Kim
Dongmyeong Lee
Seunghwan Kim
So Jeong Yun
Daehee Hwang
Ji Woong Kim
Yeukuang Hwu
Giorgio Margaritondo
Jung Ho Je
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2011-10
Issue Date: 2018-07-09T07:27:42Z
Publisher: Scientific Reports
Abstract: Abstract: Disrupted cortical cytoarchitecture in cerebellum is a typical pathology in reeler. Particularly interesting are structural problems at the cellular level: dendritic morphology has important functional implication in signal processing. Here we describe a combinatorial imaging method of synchrotron X-ray microtomography with Golgi staining, which can deliver 3-dimensional(3-D) micro-architectures of Purkinje cell(PC) dendrites, and give access to quantitative information in 3-D geometry. In reeler, we visualized in 3-D geometry the shape alterations of planar PC dendrites (i.e., abnormal 3-D arborization). Despite these alterations, the 3-D quantitative analysis of the branching patterns showed no significant changes of the 77 ± 8° branch angle, whereas the branch segment length strongly increased with large fluctuations, comparing to control. The 3-D fractal dimension of the PCs decreased from 1.723 to 1.254, indicating a significant reduction of dendritic complexity. This study provides insights into etiologies and further potential treatment options for lissencephaly and various neurodevelopmental disorders.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47264
Appears in Collections:[光電科學研究所] 期刊論文

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