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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47261

Title: Complete microscale profiling of tumor microangiogenesis A microradiological methodology reveals fundamental aspects of tumor angiogenesis and yields an array of quantitative parameters for its characterization
Authors: G. Margaritondo
Chia-Chi Chien
Ivan M. Kempson
C. L. Wang
H. S. Chen
Y. Hwu
N. Y. Chen
T. K. Lee
Cyril Petibois
Kelvin K.-C. Tsai
Ming-Sheng Liu
Kwang-Yu Chang
C. S. Yang
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2011-12
Issue Date: 2018-07-09T03:53:35Z
Abstract: Abstract: Complete profiling would substantially facilitate the fundamental understanding of tumor angiogenesis and of possible anti-angiogenesis cancer treatments. We developed an integrated synchrotron-based methodology with excellent performances: detection of very small vessels by high spatial resolution (~1 μm) and nanoparticle contrast enhancement, in vivo dynamics investigations with high temporal resolution (~1 ms), and three-dimensional quantitative morphology parametrization by computer tracing. The smallest (3-10 μm) microvessels were found to constitute >80% of the tumor vasculature and exhibit many structural anomalies. Practical applications are presented, including vessel microanalysis in xenografted tumors, monitoring the effects of anti-angiogenetic agents and in vivo detection of tumor vascular rheological properties.
Relation: 31(3)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47261
Appears in Collections:[光電科學研究所] 期刊論文

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