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Title: X-ray imaging of tumor growth in live mice by detecting gold-nanoparticle-loaded cells
Authors: G. Margaritondo
Chia-Chi Chien
Hsiang-Hsin Chen
Sheng-Feng Lai
Y. Hwu
C. S. Yang
Y. Chu
Cyril Petibois
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2012-08
Issue Date: 2018-07-09T02:48:46Z
Publisher: Scientific Reports
Abstract: Abstract: We show that sufficient concentrations of gold nanoparticles produced by an original synthesis method in EMT-6 and CT-26 cancer cells make it possible to detect the presence, necrosis and proliferation of such cells after inoculation in live mice. We first demonstrated that the nanoparticles do not interfere with the proliferation process. Then, we observed significant differences in the tumor evolution and the angiogenesis process after shallow and deep inoculation. A direct comparison with pathology optical images illustrates the effectiveness of this approach.
Appears in Collections:[Institute of Optoelectronic Sciences] Periodical Articles

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