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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47246

Title: Immunospecific targeting of CD45 expressing lymphoid cells: towards improved detection agents of the sentinel lymph node.
Authors: Benjamin Thierry
Tianqing Liu
Aidan Cousins
Chia-Chi Chien
Ivan Kempson
Sarah Thompson
Yeukuang Hwu
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2013-01
Issue Date: 2018-07-09T02:00:58Z
Publisher: CANCER LETTERS
Abstract: Abstract: This study was designed to demonstrate the potential of small nanoparticulate lymphotropic contrast agents designed to bind with high affinity to lymphoid cells overexpressing the CD45 antigen. To this end, small gold nanoparticles used as model were conjugated to anti-CD45 antibodies and injected in mice in the dorsal toe of the fore/hind paw. Chemical analysis demonstrated rapid uptake and transport of the nanoparticles in the lymphatic as well as significant retention of the nanoparticles with high binding affinity to lymphoid cells in the popliteal and axillary lymph nodes in comparison to non-targeted nanoparticles.
Relation: 328(2)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47246
Appears in Collections:[光電科學研究所] 期刊論文

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