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Title: Very small photoluminescent gold nanoparticles for multimodality biomedical imaging
Authors: Margaritondo G.
Lai SF1
Chien CC
Chen WC
Chen HH
Chen YY
Wang CL
Hwu Y
Yang CS
Chen CY
Liang KS
Petibois C
Tan HR
Tok ES
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2013-05
Issue Date: 2018-07-09T01:45:49Z
Abstract: Abstract: An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4 nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells.
Relation: 31(3)
Appears in Collections:[Institute of Optoelectronic Sciences] Periodical Articles

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