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题名: Radiotherapy of the Excretable Radioactive Gold Nanocomposite with Intratumoral Injection
作者: C. S. Yang
F.-S. Lin
C.-H. Chen
F. G. Tseng
Y. Hwu
J. K. Chen
S. Y. Lin
贡献者: 國立臺灣海洋大學:光電科學研究所
日期: 2013-08
上传时间: 2018-07-09T01:02:07Z
出版者: International Journal of Materials, Mechanics and Manufacturing
摘要: Abstract: we synthesized excretable radioactive gold nanoparticles at gum arabic (198AuNPs@GA) for radiotherapy. The nanocomposite of AuNPs@GA was first synthesized by synchrotron X-ray. After neutron activation, the nanocomposite of AuNPs@GA formed radioactive 198AuNPs@GA in which the radioisotope of 198Au can generate β particles (βmax = 960 keV) and gamma ray (Egamma = 412 keV) to kill cancer cells and suppress tumor growth. The efficacy of radiotherapy was evaluated with H460 tumor model by intratumoral injection. At day 7 after intratumoral administration of 198AuNPs@GA, the tumor was significantly suppressed over 90% (P < 0.01), compared to the controls. Intratumoral injection with 198AuNPs@GA did not cause serious weight loss of mice. After 2-weeks observation period, 198AuNPs@GA was still mainly accumulated in the tumor. Interestingly, excretion of 198AuNPs@GA in feces and urine was observed from first day to the endpoint of experiment. In this study, the radioactive 198AuNPs@GA nanocomposite not only successfully suppressed tumor growth but also could be excreted through urine and feces, eliminating possible toxic concerns of nanomaterial accumulation in vivo.
關聯: 1(3) pp.265-268
显示于类别:[光電科學研究所] 期刊論文


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