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題名: Gold nanoparticles as multimodality imaging agents for brain gliomas
作者: Y. Hwu
Sheng-Feng Lai
Bai-Hung Ko
Chia-Chi Chien
Chia-Ju Chang
Shun-Ming Yang
Hsiang-Hsin Chen
Cyril Petibois
Dueng-Yuan Hueng
Shuk-Man Ka
Ann Chen
G. Margaritondo
貢獻者: 國立臺灣海洋大學:光電科學研究所
關鍵詞: CdWO4
Glioma Cell
Advanced Photon Source
Orthotopic Xenografting
Single Photon
Emission Computer Tomography
日期: 2015-11
上傳時間: 2018-07-05T05:54:12Z
出版者: Journal of Nanobiotechnology
摘要: Abstract: Background:Nanoparticles can be used for targeted drug delivery, in particular for brain cancer therapy. However, this requires a detailed analysis of nanoparticles from the associated microvasculature to the tumor, not easy because of the required high spatial resolution. The objective of this study is to demonstrate an experimental solution of this problem, based in vivo and post-mortem whole organ imaging plus nanoscale 3-dimensional (3D) X-ray microscopy.
Results:The use of gold nanoparticles (AuNPs) as contrast agents paved the way to a detailed high-resolution three dimensional (3D) X-ray and fluorescence imaging analysis of the relation between xenografted glioma cells and the tumor-induced angiogenic microvasculature. The images of the angiogenic microvessels revealed nanoparticle leakage. Complementary tests showed that after endocytotic internalization fluorescent AuNPs allow the visible-light detection of cells.
Conclusions:AuNP-loading of cells could be extended from the case presented here to other imaging techniques. In our study, they enabled us to (1) identify primary glioma cells at inoculation sites in mice brains; (2) follow the subsequent development of gliomas. (3) Detect the full details of the tumor-related microvasculature; (4) Finding leakage of AuNPs from the tumor-related vasculature, in contrast to no leakage from normal vasculature.
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47215
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