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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47211

Title: Fourier-transform vs. quantum-cascade-laser infrared microscopes for histo-pathology: From lab to hospital?
Authors: Cyril Petibois
Abiodun Ogunleke
Vladimir Bobroff
Hsiang-Hsin Chen
Jeremy Rowlette
Maylis Delugin
Benoit Recur
Yeukuang Hwu
Contributors: 國立臺灣海洋大學:光電科學研究所
Keywords: Clinical routine
FTIR microscopy
QCL-IR imaging
3D chemical imaging
Digital pathology
Date: 2017-04
Issue Date: 2018-07-05T02:09:37Z
Publisher: TrAC - Trends in Analytical Chemistry
Abstract: Abstract: IR microscopy was first conceptualized in 1949 and the first commercial system was launched 1983. With the appearance of FPA detectors in the 90's, FTIR microscopy became a technique of choice for histology. Two decades later, the release of QCLs working in the mid-IR range refuels this promise by accelerating tremendously the acquisition of IR images for large tissue areas with high-quality spectra for chemical mapping of parameters of interest.

The new QCL-IR imaging system allows a 150× faster spectral data acquisition at equivalent S/N level. The quality of spectral data is comparable while applying spectral curve-fitting treatments, thus showing that laser sources offer reliable signal over a large spectral range. If QCL-IR imaging system seem to offer the opportunity to develop routines for anatomo-pathology, several technological challenges stand in front of us to reach this goal to define the specs of an IR microscope dedicated to hospital.
Relation: 89 pp.190-196
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47211
Appears in Collections:[光電科學研究所] 期刊論文

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