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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47207

Title: Free-Electron-Laser Coherent Diffraction Images Individual Drug-Carrying Liposome Particles in Solution
Authors: Y. Hwu
C. -F. Huang
K.S. Liang
T.L. Hsu
T.T. Lee
Y.Y. Chen
S.M. Yang
H.H. Chen
S.H. Huang
W.H. Chang
P. Chen
T.K. Lee
K.E. Peng
C.C. Chen
C.Z. Shi
Y.F. Hu
G. Margaritondo
T. Ishikawa
C.H. Wong
Contributors: 國立臺灣海洋大學:光電科學研究所
Date: 2018-01
Issue Date: 2018-07-05T01:28:57Z
Publisher: Nanoscale
Abstract: Abstract: Using the excellent performances of a SACLA (RIKEN/HARIMA, Japan) X-ray free electron laser (X-FEL), coherent diffraction imaging (CDI) was used to detect individual liposome particles in water, with or without inserted doxorubicin nanorods. This was possible because of the electron density differences between the carrier, the liposome, and the drug. The result is important since liposome nanocarriers at present dominate drug delivery systems. In spite of the low cross-section of the original ingredients, the diffracted intensity of drug-free liposomes was sufficient for spatial reconstruction yielding quantitative structural information. For particles containing doxorubicin, the structural parameters of the nanorods could be extracted from CDI. Furthermore, the measurement of the electron density of the solution enclosed in each liposome provides direct evidence of the incorporation of ammonium sulphate into the nanorods. Overall, ours is an important test for extending the X-FEL analysis of individual nanoparticles to low cross-sectional systems in solution, and also for its potential use to optimize the manufacturing of drug nanocarriers.
Relation: 10(6)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/47207
Appears in Collections:[光電科學研究所] 期刊論文

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