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Title: Identification and Phylogeny of the First T Cell Epitope Identified from a Human Gut Bacteroides Species
Authors: Maria Elisa Perez-Muñoz
Payal Joglekar
Yi-Ji Shen
Kuan Y. Chang
Daniel A. Peterson
Contributors: 國立臺灣海洋大學:資訊工程學系
NTOU:Department of Computer Science and Engineering
Date: 2015-12
Issue Date: 2018-06-04T02:58:24Z
Publisher: PLOS ONE
Abstract: Abstract:
Host T cell reactivity toward gut bacterial epitopes has been recognized as part of disease pathogenesis. However, the specificity of T cells that recognize this vast number of epitopes has not yet been well described. After colonizing a C57BL/6J germ-free mouse with the human gut symbiotic bacteria Bacteroides thetaiotaomicron, we isolated a T cell that recognized these bacteria in vitro. Using this T cell, we mapped the first known non-carbohydrate T cell epitope within the phylum Bacteroidetes. The T cell also reacted to two other additional Bacteroides species. We identified the peptide that stimulated the T cell by using a genetic approach. Genomic data from the epitope-positive and epitope-negative bacteria explain the cross-reactivity of the T cell to multiple species. This epitope degeneracy should shape our understanding of the T cell repertoire stimulated by the complex microbiome residing in the gastrointestinal tract in both healthy and disease states.
Relation: 10(12)
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46731
Appears in Collections:[資訊工程學系] 期刊論文

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