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Please use this identifier to cite or link to this item: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46465

Title: Freshwater clam extracts alleviate dyslipidaemia of tilapia fed a high-fat diet as an animal model
Authors: Sheng Chia,Huang
Jing Jen,Lin
Mong Fong,Lee
Yeuk Chuen,Liu
Bonnie Sun,Pan
Contributors: 國立臺灣海洋大學:食品科學系
Keywords: Hypocholesterolaemia
Freshwater clam
Tilapia
High-fat diet
Fatty streak
Dyslipidaemia
Date: 2016
Issue Date: 2018-05-21T02:09:23Z
Publisher: Journal of Functional Foods
Abstract: Abstract: Tilapia were used as an alternative animal model for evaluating metabolic syndrome, e.g., hyperlipidaemia and hypercholesterolaemia. Vascular lipid accumulation and inflammation of tilapia were induced by a high-fat diet (HFD) given for two weeks. The HFD triggered lipid peroxidation, high concentrations of total cholesterol and low-density lipoprotein (LDL) cholesterol in plasma, leading to hyperlipidaemia, fatty liver, and lipid accumulation in aorta intima. Tilapia fed an HFD supplemented with freshwater clam extracts (FCEs) showed improved plasma lipid profiles, reduction of liver size and decreased lipid accumulation in the liver. FCEs also enhanced plasma antioxidant status and alleviated vascular lesions in the tilapia fed an HFD. In vivo experimental results proved the atherosclerosis-preventive properties of FCEs against oxidative stress on lipid metabolism. Consequently, FCEs may serve as a potential nutraceutical ingredient to reduce the risk factors of cardiovascular diseases.
Relation: 25 pp.559-567
URI: http://ntour.ntou.edu.tw:8080/ir/handle/987654321/46465
Appears in Collections:[食品科學系] 期刊論文

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